Neutrophil-Mediated Gastrointestinal Injury
نویسندگان
چکیده
منابع مشابه
Mechanisms of neutrophil-mediated injury.
The interaction of neutrophils with endothelial cells results in damage or killing of the latter. This outcome requires alteration of the endothelial cells such thatadhesive interactions betweenncutrophils and endothelia! cells are enhanced. In addition, neutrophil stimulation must also occur. To date, the most important adhesion promoting molecules appear to involve either P-selectiii or E-sel...
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Neutrophils use cell surface molecules to communicate with their external environment. These molecules are markers reflecting neutrophil development, activation status and cell function. They are also critically important in controlling neutrophil behavior. Targeting these cell surface molecules is an attractive approach in the treatment of neutrophil-mediated conditions.
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Introduction Two murine monoclonal antibodies (CL-3 and CL-37, both F(ab')2) to human endothelial-leukocyte adhesion molecule-i (ELAM-1) were found to react immunohistochemically with rat pulmonary artery endothelial cells that had been pretreated with tumor necrosis factor (TNFa). CL-3, but not CL-37, blocked in vitro adherence ofneutrophils to TNFa-treated endothelial cells and the killing of...
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The development of experimental acute lung injury following systemic complement activation is closely related to availability of blood neutrophils. Although tissue-destructive neutrophil-derived proteinases may play a supportive role in acute pulmonary injury, it appears that oxygen radical constitute the major neutrophil product responsible for acute damage of lung tissues and cells. Intravasc...
متن کاملNeutrophil-mediated epithelial injury during transmigration: role of elastase.
Neutrophil-mediated injury to gut epithelium may lead to disruption of the epithelial barrier function with consequent organ dysfunction, but the mechanisms of this are incompletely characterized. Because the epithelial apical junctional complex, comprised of tight and adherens junctions, is responsible in part for this barrier function, we investigated the effects of neutrophil transmigration ...
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ژورنال
عنوان ژورنال: Canadian Journal of Gastroenterology
سال: 1998
ISSN: 0835-7900
DOI: 10.1155/1998/398384